ea0029p34 | Adrenal cortex | ICEECE2012
Ronchi C.
, Leich E.
, Sbiera S.
, Rosenwald A.
, Allolio B.
, Fassnacht M.
Introduction: The genetic mechanisms underlying adrenocortical tumor development are still largely unknown. We used high-resolution single nucleotide polymorphism (SNP) microarrays to detect copy number alterations (CNAs) and copy neutral losses of heterozygosity (cnLOH) in cortisol-secreting adrenocortical adenomas (ACAs). We focused on microalterations aiming to discover new candidate genes involved in early tumorigenesis and/or autonomous cortisol secretion.<p class="ab...